Adaptive survival signaling can promote resistance to individual kinase inhibitors. A new study used a pathway-based approach to characterize shared kinome-wide rewiring mechanisms across multiple kinase inhibitors and developed rational drug-combination approaches that target cross-talk between two signaling pathways.
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References
Duncan, J. S. et al. Cell 149, 307–321 (2012).
Bai, Y. et al. Cancer Res. 74, 7217–7228 (2014).
Donnella, H. J. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-018-0081-9 (2018).
Cancer Genome Atlas Network. Nature 490, 61–70 (2012).
Rodon, J., Dienstmann, R., Serra, V. & Tabernero, J. Nat. Rev. Clin. Oncol. 10, 143–153 (2013).
Bantscheff, M. et al. Nat. Biotechnol. 25, 1035–1044 (2007).
den Hollander, J. et al. Blood 116, 1498–1505 (2010).
Brewer Savannah, K. J. et al. Clin. Cancer Res. 18, 4633–4645 (2012).
Katsha, A. et al. Clin. Cancer Res. 23, 3756–3768 (2017).
Zheng, X. et al. Oncogene 37, 502–511 (2018).
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Palve, V., Kuenzi, B.M. & Rix, U. Unraveling the rewired network. Nat Chem Biol 14, 746–747 (2018). https://doi.org/10.1038/s41589-018-0083-7
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DOI: https://doi.org/10.1038/s41589-018-0083-7
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