Catalytic activity is a critical protein function, but its natural evolution has never been observed. Researchers have now revealed the mutations and biochemical mechanisms by which two ancient nonenzymatic proteins acquired catalytic activity.
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References
Clifton, B. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-018-0043-2 (2018).
Kaltenbach, M. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-018-0042-3 (2018).
Mak, W. S. & Siegel, J. B. Curr. Opin. Struct. Biol. 27, 87–94 (2014).
Pauling, L. & Zuckerkandl, E. Acta Chem. Scand. 17, S9–S16 (1963).
Harms, M. J. & Thornton, J. W. Curr. Opin. Struct. Biol. 20, 360–366 (2010).
Steindel, P. A., Chen, E. H., Wirth, J. D. & Theobald, D. L. Protein Sci. 25, 1319–1331 (2016).
Anderson, D. P. et al. eLife 5, e10147 (2016).
Lynch, V. J., May, G. & Wagner, G. P. Nature 480, 383–386 (2011).
Natarajan, C. et al. Science 354, 336–339 (2016).
Tzul, F. O., Vasilchuk, D. & Makhatadze, G. I. Proc. Natl. Acad. Sci. USA 114, E1627–E1632 (2017).
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Harms, M.J. Enzymes emerge by upcycling. Nat Chem Biol 14, 526–527 (2018). https://doi.org/10.1038/s41589-018-0064-x
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DOI: https://doi.org/10.1038/s41589-018-0064-x
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