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Cancer genomics

Experimental evolution of cancer chromosomal changes

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Experimental genome evolution of normal human cells reveals an intrinsic propensity to develop cancer-associated chromosomal alterations.

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Fig. 1: Overview of experimental outline and correlations between first-round-evolved populations and cancer aneuploidies.

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Acknowledgements

M.G. acknowledges funding from the UKRI Medical Research Council.

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Authors and Affiliations

  1. Barts Cancer Institute, Queen Mary University of London, London, UK

    Molly A. Guscott & Sarah E. McClelland

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  1. Molly A. Guscott
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  2. Sarah E. McClelland
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Correspondence to Sarah E. McClelland.

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The authors declare no competing interests.

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Guscott, M.A., McClelland, S.E. Experimental evolution of cancer chromosomal changes. Nat Genet 56, 743–745 (2024). https://doi.org/10.1038/s41588-024-01742-6

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