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Gene regulation

Enhancer contacts during embryonic development show diverse interaction modes and modest yet significant increases upon gene activation

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The exact relationship between 3D chromatin interactions and enhancer function is unclear. By probing three-dimensional enhancer interactions in developing embryos, two studies now show nuanced dynamics in tissue-specific contexts and reveal how moderately increased enhancer–promoter interactions coincide with functionality.

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Fig. 1: High-resolution mapping of enhancer chromatin interactions in vivo reveals principles of activity-dependent three-dimensional contacts.

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Authors and Affiliations

  1. Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Center for Regenerative Therapies, Berlin, Germany

    Daniel M. Ibrahim

  2. Max Planck Institute for Molecular Genetics, Berlin, Germany

    Daniel M. Ibrahim

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  1. Daniel M. Ibrahim
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Correspondence to Daniel M. Ibrahim.

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The author declares no competing interests.

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Ibrahim, D.M. Enhancer contacts during embryonic development show diverse interaction modes and modest yet significant increases upon gene activation. Nat Genet 56, 558–560 (2024). https://doi.org/10.1038/s41588-024-01700-2

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