We show that in addition to promoter activation, MYC drives cancer progression by activating transcriptional enhancers via a distinct mechanism. MYC cooperates with several other proteins at these cis-regulatory regions to change the epigenome and promote recruitment of RNA polymerase II and enhancer transcription.
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References
Baluapuri, A., Wolf, E. & Eilers, M. Target gene-independent functions of MYC oncoproteins. Nat. Rev. Mol. Cell Biol. 21, 255–267 (2020). A review article that describes the transcriptional mechanisms underlying MYC function.
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This is a summary of: Jakobsen, S. T. et al. MYC activity at enhancers drives prognostic transcriptional programs through an epigenetic switch. Nat. Genet. https://doi.org/10.1038/s41588-024-01676-z (2024).
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MYC activates transcriptional enhancers to drive cancer progression. Nat Genet 56, 567–568 (2024). https://doi.org/10.1038/s41588-024-01677-y
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DOI: https://doi.org/10.1038/s41588-024-01677-y
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