Skip to main content
SpringerLink
Log in

Chromatin organization

Building chromatin from the ground up

  • News & Views
  • Published:

From Nature Genetics

View current issue Submit your manuscript

A common architectural feature of the genome in many organisms is chromatin domains. A synthetic biology approach now builds chromatin domains from scratch and identifies some of the minimal components needed for their formation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1: An approach to build chromatin in vitro.

References

  1. Misteli, T. Cell 183, 28–45 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Oberbeckmann et al. Nat. Genet. https://doi.org/10.1038/s41588-023-01649-8 (2024).

    Article  PubMed  Google Scholar 

  3. Krietenstein, N. et al. Cell 167, 709–721.e12 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Nuebler, J., Fudenberg, G., Imakaev, M., Abdennur, N. & Mirny, L. A. Proc. Natl Acad. Sci. USA 115, e6697–e6706 (2018).

    Article  CAS  PubMed  PubMed Central  ADS  Google Scholar 

  5. Nora, E. P. et al. Cell 169, 930–944.e22 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Hsieh, T. S. et al. Mol. Cell 78, 539–553.e8 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Gabriele, M. et al. Science 376, 496–501 (2022).

    Article  CAS  PubMed  PubMed Central  ADS  Google Scholar 

  8. Eustermann, S. et al. Nat. Rev. Mol. Cell Biol. https://doi.org/10.1038/s41580-023-00683-y (2023).

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. National Cancer Institute, National Institutes of Health, Bethesda, MD, USA

    Theodore Busby III & Tom Misteli

Authors
  1. Theodore Busby III
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Tom Misteli
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Tom Misteli.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Busby, T., Misteli, T. Building chromatin from the ground up. Nat Genet 56, 360–361 (2024). https://doi.org/10.1038/s41588-024-01666-1

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41588-024-01666-1

  • Springer Nature America, Inc.

Search

Navigation