New research reports that paused RNA polymerase II (RNAPII) enhances the targeting and activity of BAF chromatin remodelers. These findings suggest a new paradigm for understanding how the collaborative action of chromatin remodelers and the transcriptional machinery govern cell-type-specific chromatin accessibility.
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Chick, B.Y., Hargreaves, D.C. RNA polymerase II promoter-proximal pausing promotes BAF chromatin binding and remodeling. Nat Genet 56, 19–20 (2024). https://doi.org/10.1038/s41588-023-01628-z
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DOI: https://doi.org/10.1038/s41588-023-01628-z
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