A new study combining experimental treatments of human blood cells from thousands of individuals with flow-cytometry-based phenotyping and then genome-wide association analyses identifies genetic loci associated with non-resting cell states. Integrating the results with disease association signals yields insights into the underlying biology.
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Johnson, A.D. Cell perturbation and lasers illuminate the genetics of latent blood cell traits. Nat Genet 56, 16–18 (2024). https://doi.org/10.1038/s41588-023-01623-4
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DOI: https://doi.org/10.1038/s41588-023-01623-4
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