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Immunogenetics

Taming the HLA for single-cell genomics

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Variants in the HLA region on chromosome 6 are strongly associated with many immune-related diseases. A method to construct personalized HLA genomes from single-cell RNA sequencing data, coupled with single-cell HLA expression quantitative trait loci modeling, identifies how genetic variants influence HLA gene expression across cell states.

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Fig. 1: A method for constructing personalized HLA genomes from scRNA-seq data improves eQTL detection.

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Authors and Affiliations

  1. Genes and Human Disease Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA

    Jennifer A. Kelly, Kandice L. Tessneer & Patrick M. Gaffney

Authors
  1. Jennifer A. Kelly
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  2. Kandice L. Tessneer
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  3. Patrick M. Gaffney
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Corresponding author

Correspondence to Patrick M. Gaffney.

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The authors declare no competing interests.

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Kelly, J.A., Tessneer, K.L. & Gaffney, P.M. Taming the HLA for single-cell genomics. Nat Genet 55, 2025–2026 (2023). https://doi.org/10.1038/s41588-023-01590-w

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