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Enhancing polygenic risk prediction in diverse populations: opportunities and challenges

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Polygenic risk scores (PRSs) are increasingly able to predict complex traits; however, they perform suboptimally in populations not of European ancestry. We present CT-SLEB, a powerful method that enables the calculation of PRSs from multi-ancestry samples and provides insights into the opportunities and challenges of enhancing polygenic risk prediction across populations of diverse ancestry.

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Fig. 1: The CT-SLEB method and comparison of prediction accuracy.

References

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This is a summary of: Zhang, H. et al. A new method for multiancestry polygenic prediction improves performance across diverse populations. Nat. Genet. https://doi.org/10.1038/s41588-023-01501-z (2023).

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Enhancing polygenic risk prediction in diverse populations: opportunities and challenges. Nat Genet 55, 1621–1622 (2023). https://doi.org/10.1038/s41588-023-01502-y

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