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Somatic mutations

Our ancestry dictates clonal architecture and skin cancer susceptibility

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Incidence of keratinocyte skin cancer varies markedly between populations living in different areas of the world. A detailed analysis of somatic mutations in the normal skin of individuals from the UK and Singapore reveals different patterns of clonal mutational landscapes that could contribute to differential risk.

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Fig. 1: UK donors show differences in skin pigmentation and higher frequencies of keratinocyte risk alleles, including some involved in inflammatory pathways.

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Acknowledgements

J.D. is supported by US Veterans Administration Merit Grant 1 I01 BX004495.

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Authors and Affiliations

  1. Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA

    Marco De Dominici & James DeGregori

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  1. Marco De Dominici
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  2. James DeGregori
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Correspondence to James DeGregori.

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The authors declare no competing interests.

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De Dominici, M., DeGregori, J. Our ancestry dictates clonal architecture and skin cancer susceptibility. Nat Genet 55, 1428–1429 (2023). https://doi.org/10.1038/s41588-023-01467-y

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