The three-dimensional organization of mammalian chromosomes can regulate transcription. Whether transcription itself influences genome structure has remained a source of debate. Using sensitive genome-wide readouts, two recent studies describe the involvement of transcription on genome architecture by different mechanisms.
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Noordermeer, D. RNA Pol II enters the ring of cohesin-mediated loop extrusion. Nat Genet 55, 1256–1258 (2023). https://doi.org/10.1038/s41588-023-01463-2
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DOI: https://doi.org/10.1038/s41588-023-01463-2
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