Cross-ancestry genome-wide association meta-analyses of neuroimaging genetics data from European and East Asian populations identified 339 genetic variant–hippocampal volumetric trait associations (23 new). Further cross-ancestry analyses revealed similar genetic effects on hippocampal volumetric traits between ancestries, with improved fine-mapping precision and predictive accuracy of polygenic scores in the under-represented East Asian population.
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This is a summary of: Liu, N. et al. Cross-ancestry genome-wide association meta-analyses of hippocampal and subfield volumes. Nat. Gen. https://doi.org/10.1038/s41588-023-01425-8 (2023).
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Cross-ancestry genetic discovery for hippocampal volumetric traits. Nat Genet 55, 1086–1087 (2023). https://doi.org/10.1038/s41588-023-01427-6
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DOI: https://doi.org/10.1038/s41588-023-01427-6
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