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Genes with immune functions modulate key traits associated with Down syndrome in mice

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An extra copy of a chromosome region that includes four genes encoding interferon receptors contributes to immune dysregulation, heart malformations, developmental delays, cognitive deficits and craniofacial abnormalities in a mouse model of Down syndrome.

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Fig. 1: The Ifnr gene cluster contributes to multiple traits characteristic of Down syndrome in mice.

References

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This is a summary of: Waugh, K. A. et al. Triplication of the interferon receptor locus contributes to hallmarks of Down syndrome in a mouse model. Nat. Genet. https://doi.org/10.1038/s41588-023-01399-7 (2023).

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Genes with immune functions modulate key traits associated with Down syndrome in mice. Nat Genet 55, 910–911 (2023). https://doi.org/10.1038/s41588-023-01400-3

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