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Identifying individuals at extreme risk of venous thromboembolism using polygenic risk scores

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Current risk assessment and treatment strategies for venous thromboembolism (VTE) consider genetic factors only in a limited way. New work shows a more pervasive role of common variants in VTE risk, inspiring genetic predictors that surpass and complement individual clinical risk factors and monogenic thrombophilia testing.

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Fig. 1: Key performance milestones achieved in polygenic risk prediction for venous thromboembolism.

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Author information

Author notes

  1. These authors contributed equally: Michael Chong, Guillaume Paré.

Authors and Affiliations

  1. Population Health Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton, Ontario, Canada

    Michael Chong & Guillaume Paré

  2. Thrombosis and Atherosclerosis Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton, Ontario, Canada

    Michael Chong & Guillaume Paré

  3. Department of Pathology and Molecular Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada

    Michael Chong & Guillaume Paré

  4. Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada

    Michael Chong & Guillaume Paré

  5. Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada

    Guillaume Paré

Authors
  1. Michael Chong
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  2. Guillaume Paré
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Corresponding authors

Correspondence to Michael Chong or Guillaume Paré.

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Competing interests

G.P. has received consulting fees from Illumina, Bayer and Lifelabs. M.C. has received consulting fees from Bayer and Lifelabs.

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Chong, M., Paré, G. Identifying individuals at extreme risk of venous thromboembolism using polygenic risk scores. Nat Genet 55, 358–360 (2023). https://doi.org/10.1038/s41588-023-01330-0

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