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Cancer metastasis

Skip to the end: metastasis before tumorigenesis

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Mutations in the sodium channel NALCN promote epithelial cell shedding and dissemination independent of oncogenic transformation. This observation suggests that metastasis may not uniformly represent the end stage of carcinogenesis but can occur before oncogenic transformation.

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Fig. 1: An alternative model of metastasis.

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Acknowledgements

A.B. has received research funding from The Pew Charitable Trusts, Pershing Square Sohn Cancer Research Alliances, Joe W. and Dorothy Dorsett Brown Foundation, W.M. Keck Foundation, American Brain Tumor Association, Alan and Sandra Gerry Metastasis and Tumor Ecosystems Center, American Association for Cancer Research, National Institutes of Health, STARR Cancer Consortium, MSKCC Center for Experimental Therapeutics and FM Kirby Foundation.

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Authors and Affiliations

  1. Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY, USA

    Ana Rita Nobre & Adrienne Boire

  2. Human Oncology and Pathogenesis Program, Brain Tumor Center, Memorial Sloan Kettering Cancer Center, New York, NY, USA

    Adrienne Boire

Authors
  1. Ana Rita Nobre
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  2. Adrienne Boire
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Corresponding author

Correspondence to Adrienne Boire.

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Competing interests

A.B. holds an unpaid position on the scientific advisory board of Evren Scientific, and is an inventor on the following patents: 62/258,044, 10413522 and 63/052,139. A.R.N. declares no competing interests.

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Nobre, A.R., Boire, A. Skip to the end: metastasis before tumorigenesis. Nat Genet 54, 1774–1775 (2022). https://doi.org/10.1038/s41588-022-01228-3

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  • DOI: https://doi.org/10.1038/s41588-022-01228-3

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