A new study identifies prolyl hydroxylation of histone H3 as a signal for the recruitment of KDM5A, altering H3K4me3 and gene expression. H3P16oh is independent of the HIF hypoxia-sensing pathway and provides a further layer of complexity to oxygen-sensitive chromatin modifications.
This is a preview of subscription content, log in via an institution to check access.
References
Kaelin, W. G. Jr. & Ratcliffe, P. J. Mol. Cell 30, 393–402 (2008).
Semenza, G. L. Cell 148, 399–408 (2012).
Ivan, M. & Kaelin, W. G. Jr Mol. Cell 66, 772–779 (2017).
Liu, X. et al. Nat. Genet. https://doi.org/10.1038/s41588-022-01212-x (2022).
Howe, F. S. et al. Mol. Cell 55, 733–744 (2014).
Nelson, C. J., Santos-Rosa, H. & Kouzarides, T. Cell 126, 905–916 (2006).
Cockman, M. E. et al. eLife 8, e46490 (2019).
Cano-Rodriguez, D. et al. Nat. Commun. 7, 12284 (2016).
Douillet, D. et al. Nat. Genet. 52, 615–625 (2020).
Brown, D. A. et al. Cell Rep. 20, 2313–2327 (2017).
Chakraborty, A. A. et al. Science 363, 1217–1222 (2019).
Batie, M. et al. Science 363, 1222–1226 (2019).
Thienpont, B. et al. Nature 537, 63–68 (2016).
Ortmann, B. M. et al. Nat. Genet. 53, 1022–1035 (2021).
Dion, M. F. et al. Science 315, 1405–1408 (2007).
Ferrari, P. & Strubin, M. Nucleic Acids Res. 43, 3972–3985 (2015).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing interests.
Rights and permissions
About this article
Cite this article
Nathan, J.A. Chromatin oxygen sensing by histone H3 prolyl hydroxylation. Nat Genet 54, 1585–1586 (2022). https://doi.org/10.1038/s41588-022-01201-0
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41588-022-01201-0
- Springer Nature America, Inc.