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ENDOGENOUS RETROVIRUSES

Endogenous retroviruses steer transcriptional condensates away from pluripotency

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The impact of endogenous retrovirus silencing during mammalian development is poorly understood. A new study shows that their abnormal reactivation in pluripotent cells dismantles key gene regulatory networks by perturbing transcriptional condensates linked to super-enhancer function.

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Fig. 1: Trim28 enables chromatin silencing of ERV sequences, whereas pluripotency is maintained through super-enhancer occupancy of transcriptional condensates.

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Acknowledgements

E.J.G. is supported by a Cancer Prevention & Research Institute of Texas Recruitment of First-Time, Tenure-Track Faculty Member Award grant RR210077 and by the Cecil H. and Ida Green Center for Reproductive Biology Sciences. Apologies to my colleagues whose work cannot be cited owing to space constraints.

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Authors and Affiliations

  1. Cecil H. and Ida Green Center for Reproductive Biology Sciences and the Division of Basic Research, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX, USA

    Edward J. Grow

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  1. Edward J. Grow
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Correspondence to Edward J. Grow.

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Grow, E.J. Endogenous retroviruses steer transcriptional condensates away from pluripotency. Nat Genet 54, 1068–1069 (2022). https://doi.org/10.1038/s41588-022-01111-1

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