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PLANT GENOMICS

Graph pangenomes find missing heritability

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The use of association studies to identify candidate genes for complex biological traits in plants has been challenging due to a reliance on single reference genomes, leading to missing heritability. Graphical pangenomes and the identification of causal variants help overcome this and provide an important advance for crop breeding.

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Fig. 1: Graph pangenomes capture the genomic diversity that underlies the observed phenotypic diversity and maintains this structural variation information within the context of linear chromosomes.

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Authors and Affiliations

  1. School of Biological Sciences and Centre for Applied Bioinformatics, University of Western Australia, Perth, WA, Australia

    David Edwards

  2. School of Biological Sciences and Institute of Agriculture, University of Western Australia, Perth, WA, Australia

    Jacqueline Batley

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  1. David Edwards
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  2. Jacqueline Batley
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Correspondence to David Edwards or Jacqueline Batley.

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The authors declare no competing interests.

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Edwards, D., Batley, J. Graph pangenomes find missing heritability. Nat Genet 54, 919–920 (2022). https://doi.org/10.1038/s41588-022-01099-8

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