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TRANSPOSABLE ELEMENTS

Walking the LINEs hidden in the dark matter of the genome

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The function of transposable elements present in mammalian genomes remains an enigma. In this issue, Bodega, Abrignani and colleagues show that LINE1-containing transcripts are key regulators of T cell effector function and exhaustion.

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Fig. 1: LINE1 intronic elements are spliced into CD4+ T cell effector genes.

References

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Authors and Affiliations

  1. Department of Infectious Diseases, Integrative Virology, Heidelberg University Hospital, Heidelberg, Germany

    Marina Lusic

  2. German Center for Infection Research (DZIF), Heidelberg, Germany

    Marina Lusic

  3. Epigenomics & Single Cell Biophysics Group, Department of Cell Biology FNWI, Radboud University, Nijmegen, The Netherlands

    Musa M. Mhlanga

  4. Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands

    Musa M. Mhlanga

  5. Radboud Institute for Molecular Life Sciences, Nijmegen, The Netherlands

    Musa M. Mhlanga

Authors
  1. Marina Lusic
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  2. Musa M. Mhlanga
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Correspondence to Musa M. Mhlanga.

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The authors declare no competing interests.

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Lusic, M., Mhlanga, M.M. Walking the LINEs hidden in the dark matter of the genome. Nat Genet 54, 98–99 (2022). https://doi.org/10.1038/s41588-021-01003-w

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  • DOI: https://doi.org/10.1038/s41588-021-01003-w

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