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3D GENOMICS

MAZ regulates chromatin domain insulation and genome architecture

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Similar to CTCF, MAZ insulates repressed posterior Hoxa genes from the spreading of anterior active regulatory cues during motoneuron differentiation. This discovery provides new perspectives to understand chromatin organization and insulation.

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Fig. 1: MAZ controls activation of the HoxA cluster.

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Acknowledgements

G.A. is supported by the Swiss National Science Foundation (PP00P3_176802). F.D. is supported by the Swiss National Science Foundation (P400PB_194334).

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Authors and Affiliations

  1. Department of Genetic Medicine and Development, Faculty of Medicine, University of Geneva, Geneva, Switzerland

    Fabrice Darbellay, Raquel Rouco & Guillaume Andrey

  2. Institute of Genetics and Genomics in Geneva (iGE3), University of Geneva, Geneva, Switzerland

    Fabrice Darbellay, Raquel Rouco & Guillaume Andrey

  3. Environmental Genomics and Systems Biology Division, Lawrence Berkeley Laboratories, Berkeley, CA, USA

    Fabrice Darbellay

Authors
  1. Fabrice Darbellay
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  2. Raquel Rouco
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  3. Guillaume Andrey
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Correspondence to Guillaume Andrey.

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The authors declare no competing interests.

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Darbellay, F., Rouco, R. & Andrey, G. MAZ regulates chromatin domain insulation and genome architecture. Nat Genet 54, 96–97 (2022). https://doi.org/10.1038/s41588-021-00995-9

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