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WOMEN’S HEALTH

Using advanced spatial and single-cell transcriptomics to characterize the human endometrium

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The human endometrium exhibits complex signaling cascades mediated by spatial–temporal cellular interactions. Understanding the normal endometrial microenvironment is the first step towards understanding diseases of endometrial dysfunction.

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Fig. 1: The endometrium has a crucial role in female health.

References

  1. Greaves, E., Critchley, H. O. D., Horne, A. W. & Saunders, P. T. K. Acta Obstet. Gynecol. Scand. 96, 644–658 (2017).

    Article  Google Scholar 

  2. Maurya, V. K., DeMayo, F. J. & Lydon, J. P. Front. Cell. Dev. Biol. 9, 640907 (2021).

    Article  Google Scholar 

  3. Garcia-Alonso, L. Nat. Genet. https://doi.org/10.1038/s41588-021-00972-2 (2021).

  4. Wang, W. et al. Nat. Med. 26, 1644–1653 (2020).

    Article  CAS  Google Scholar 

  5. Kelleher, A. M., DeMayo, F. J. & Spencer, T. E. Endocr. Rev. 40, 1424–1445 (2019).

    Article  Google Scholar 

  6. Tempest, N., Maclean, A. & Hapangama, D. K. Int. J. Mol. Sci. 19, 3240 (2018).

    Article  Google Scholar 

  7. Burney, R. O. et al. Endocrinology 148, 3814–3826 (2007).

    Article  CAS  Google Scholar 

  8. Bulun, S. E. et al. Endocr. Rev. 40, 1048–1079 (2019).

    Article  Google Scholar 

  9. Flores, V. A., Vanhie, A., Dang, T. & Taylor, H. S. J. Clin. Endocrinol. Metab. 103, 4561–4568 (2018).

    Article  Google Scholar 

  10. Zhou, W., Menkhorst, E. & Dimitriadis, E. FASEB J. 35, e21784 (2021).

    CAS  PubMed  Google Scholar 

  11. Boretto, M. et al. Development 144, 1775–1786 (2017).

    CAS  PubMed  Google Scholar 

  12. Vallve-Juanico, J., Houshdaran, S. & Giudice, L. C. Hum. Reprod. Update 25, 564–591 (2019).

    Article  Google Scholar 

  13. Boretto, M. et al. Nat. Cell Biol. 21, 1041–1051 (2019).

    Article  CAS  Google Scholar 

  14. Turco, M. Y. et al. Nat. Cell Biol. 19, 568–577 (2017).

    Article  CAS  Google Scholar 

  15. Rawlings, T. M. et al. eLife 10, e69603 (2021).

    Article  Google Scholar 

Download references

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Correspondence to Shannon M. Hawkins.

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Wang, X., Hawkins, S.M. Using advanced spatial and single-cell transcriptomics to characterize the human endometrium. Nat Genet 53, 1628–1630 (2021). https://doi.org/10.1038/s41588-021-00982-0

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