Oncogene amplification is a major driver of tumorigenesis; yet, the mechanisms generating amplification are only partially understood. New research reports on the identification of a new focal amplification pattern termed ‘seismic amplification’ that is hypothesized to originate from recombination between extrachromosomal DNA circles.
This is a preview of subscription content, log in via an institution to check access.
References
Li, Y. et al. Nature 578, 112–121 (2020).
Stephens, P. J. et al. Cell 144, 27–40 (2011).
Zhang, C. Z. et al. Nature 522, 179–184 (2015).
Maciejowski, J. et al. Cell 163, 1641–1654 (2015).
Umbreit, N. T. et al. Science 368, eaba0712 (2020).
Shoshani, O. et al. Nature 591, 137–141 (2021).
Rosswog, C. et al. Nat. Genet. https://doi.org/10.1038/s41588-021-00951-7 (2021).
Tanaka, H. & Watanabe, T. Trends Cancer 6, 462–477 (2020).
Rausch, T. et al. Cell 148, 59–71 (2012).
Cowell, J. K. & Miller, O. J. Chromosoma 88, 216–221 (1983).
McClintock, B. Cold Spring Harb. Symp. Quant. Biol. 9, 72–81 (1941).
Bignell, G. R. et al. Genome Res. 17, 1296–1303 (2007).
Hadi, K. et al. Cell 183, 197–210 (2020).
Garsed, D. W. et al. Cancer Cell 26, 653–667 (2014).
Shimizu, N. Mutagenesis 26, 119–123 (2011).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Pellman, D., Zhang, CZ. Decoding complex patterns of oncogene amplification. Nat Genet 53, 1626–1627 (2021). https://doi.org/10.1038/s41588-021-00974-0
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41588-021-00974-0
- Springer Nature America, Inc.