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CANCER EPIGENETICS

Epigenomic contributions to tumor cell heterogeneity and plasticity

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A Publisher Correction to this article was published on 20 October 2021

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Heterogeneity in brain tumors has been viewed through many lenses—from microscopes and experimental models to ‘omic’ analysis at the tissue and single-cell levels. Two studies now characterize patterns of DNA methylation and gene expression in single cells to reveal epigenomic underpinnings of cellular heterogeneity and plasticity in exquisite detail, including mechanistic insight into cellular transitions between stem-like and differentiated-like states.

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Fig. 1: Epigenetic mechanisms contributing to tumor cell heterogeneity and plasticity.

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Authors and Affiliations

  1. Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA

    Radhika Mathur & Joseph F. Costello

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  1. Radhika Mathur
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  2. Joseph F. Costello
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Correspondence to Joseph F. Costello.

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The authors declare no competing interests.

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Mathur, R., Costello, J.F. Epigenomic contributions to tumor cell heterogeneity and plasticity. Nat Genet 53, 1403–1404 (2021). https://doi.org/10.1038/s41588-021-00932-w

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