Stretches of non-coding DNA that have remained identical across millions of years of evolution are typically assumed to have functional regulatory roles that would be compromised by any amount of nucleotide substitution. A new study finds that these ultraconserved regions are more robust to mutagenesis than their level of conservation would suggest.
References
Siepel, A. et al. Genome Res 15, 1034–1050 (2005).
Zoonomia Consortium. Nature 587, 240–245 (2020).
Snetkova, V. et al. Nat. Genet. https://doi.org/10.1038/s41588-021-00812-3 (2021).
Levine, M. Curr. Biol. 20, R754–R763 (2010).
Osterwalder, M. et al. Nature 554, 239–243 (2018).
Kryukov, G. V., Schmidt, S. & Sunyaev, S. Hum. Mol. Genet. 14, 2221–2229 (2005).
Bejerano, G. et al. Science 304, 1321–1325 (2004).
Townsley, K. G., Brennand, K. J. & Huckins, L. M. Nat. Neurosci. 23, 1509–1521 (2020).
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Pittman, M., Pollard, K.S. Ultraconservation of enhancers is not ultranecessary. Nat Genet 53, 429–430 (2021). https://doi.org/10.1038/s41588-021-00839-6
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DOI: https://doi.org/10.1038/s41588-021-00839-6
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