Skip to main content
SpringerLink
Log in

FUNCTIONAL GENOMICS

Setting new boundaries with transcription and CTCF

  • News & Views
  • Published:

From Nature Genetics

View current issue Submit your manuscript

How do boundary elements divide chromosomes into domains? A new study uses random genomic insertions to show how small genomic fragments can shape chromatin folding through the interplay of loop extrusion and compartmentalization. Spoiler: context matters.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1: A 2-kb insertion containing a promoter creates a new boundary.

References

  1. Kimura, A. & Horikoshi, M. Genes Cells 9, 499–508 (2004).

    Article  CAS  Google Scholar 

  2. Zhang, D. et al. Nat. Genet. https://doi.org/10.1038/s41588-020-0680-8 (2020).

  3. Rowley, M. J. & Corces, V. G. Nat. Rev. Genet. 19, 789–800 (2018).

    Article  CAS  Google Scholar 

  4. Nora, E. P. et al. Cell 169, 930–944.e22 (2017).

    Article  CAS  Google Scholar 

  5. Wutz, G. et al. EMBO J. 36, 3573–3599 (2017).

    Article  CAS  Google Scholar 

  6. Hansen, A. S. et al. Mol. Cell 76, 395–411.e13 (2019).

    Article  CAS  Google Scholar 

  7. Saldaña-Meyer, R. et al. Mol. Cell 76, 412–422.e5 (2019).

    Article  Google Scholar 

  8. Busslinger, G. A. et al. Nature 544, 503–507 (2017).

    Article  CAS  Google Scholar 

  9. Schwarzer, W. et al. Nature 551, 51–56 (2017).

    Article  Google Scholar 

  10. Tsujimura, T. et al. eLife 9, e47980 (2020).

    Article  CAS  Google Scholar 

  11. Rao, S. S. P. et al. Cell 171, 305–320.e24 (2017).

    Article  CAS  Google Scholar 

  12. Rhodes, J. D. P. et al. Cell Rep. 30, 820–835.e10 (2020).

    Article  CAS  Google Scholar 

  13. Barutcu, A. R. et al. EMBO Rep. 20, e48068 (2019).

    Article  CAS  Google Scholar 

  14. Jiang, Y. et al. Genome Biol. 21, 158 (2020).

    Article  CAS  Google Scholar 

  15. Fudenberg, G. et al. Preprint at bioRxiv https://doi.org/10.1101/800060 (2019).

  16. Schwessinger, R. et al. Preprint at bioRxiv https://doi.org/10.1101/724005 (2019).

Download references

Author information

Authors and Affiliations

  1. Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA

    Erika C. Anderson & Elphège P. Nora

  2. Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, USA

    Erika C. Anderson & Elphège P. Nora

Authors
  1. Erika C. Anderson
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Elphège P. Nora
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Elphège P. Nora.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Anderson, E.C., Nora, E.P. Setting new boundaries with transcription and CTCF. Nat Genet 52, 1003–1004 (2020). https://doi.org/10.1038/s41588-020-0704-4

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41588-020-0704-4

  • Springer Nature America, Inc.

This article is cited by

Search

Navigation