Pachytene Piwi-interacting RNAs (piRNAs) are abundant small non-coding RNAs expressed in mammalian germ lines. A new study indicates that, among the diverse pool of piRNA sequences, a small number act as highly selective guides that induce cleavage of coding and non-coding transcripts, thus promoting piRNA generation and regulating gene expression.
References
Lisitskaya, L., Aravin, A. A. & Kulbachinskiy, A. Nat. Commun. 9, 5165 (2018).
Ozata, D. M., Gainetdinov, I., Zoch, A., O’Carroll, D. & Zamore, P. D. Nat. Rev. Genet. 20, 89–108 (2019).
Aravin, A. A., Sachidanandam, R., Girard, A., Fejes-Toth, K. & Hannon, G. J. Science 316, 744–747 (2007).
Aravin, A. A. et al. Mol. Cell 31, 785–799 (2008).
Kuramochi-Miyagawa, S. et al. Genes Dev. 22, 908–917 (2008).
Aravin, A. et al. Nature 442, 203–207 (2006).
Girard, A., Sachidanandam, R., Hannon, G. J. & Carmell, M. A. Nature 442, 199–202 (2006).
Lau, N. C. et al. Science 313, 363–367 (2006).
Özata, D. M. et al. Nat. Ecol. Evol. 4, 156–168 (2020).
Vourekas, A. et al. Nat. Struct. Mol. Biol. 19, 773–781 (2012).
Dai, P. et al. Cell 179, 1566–1581.e16 (2019).
Homolka, D. et al. Cell Rep. 12, 418–428 (2015).
Wu, P.-S. et al. Nat. Genet. https://doi.org/10.1038/s41588-020-0657-7 (2020).
Koonin, E. V., Makarova, K. S., Wolf, Y. I. & Krupovic, M. Nat. Rev. Genet. 21, 119–131 (2020).
Aravin, A. A. et al. Curr. Biol. 11, 1017–1027 (2001).
Harms, A., Brodersen, D. E., Mitarai, N. & Gerdes, K. Mol. Cell 70, 768–784 (2018).
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Aravin, A.A. Pachytene piRNAs as beneficial regulators or a defense system gone rogue. Nat Genet 52, 644–645 (2020). https://doi.org/10.1038/s41588-020-0656-8
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DOI: https://doi.org/10.1038/s41588-020-0656-8
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