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CANCER EVOLUTION

Evolutionary dependencies show paths to cancer development

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Patterns of co-occurring and mutually exclusive mutations reveal synergistic interactions among cancer driver genes. A new study functionally confirms these interactions and builds the pairwise relationships into networks of pathway disruption that have better predictive power than specific mutations alone.

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Fig. 1: Paths of cancer development revealed by evolutionary dependency.

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Authors and Affiliations

  1. MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK

    Martin S. Taylor

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  1. Martin S. Taylor
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Correspondence to Martin S. Taylor.

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The author declares no competing interests.

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Taylor, M.S. Evolutionary dependencies show paths to cancer development. Nat Genet 52, 1135–1136 (2020). https://doi.org/10.1038/s41588-020-00728-4

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