A new study presents a powerful experimental approach, CRISPRi-FlowFISH, for mapping regulatory interactions, and uses it to characterize thousands of putative enhancer–gene pairs. The results suggest that most current approaches for predicting enhancer–gene interactions perform poorly, but a simple mathematical model combining distance with enhancer activity shows promise.
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D.J.G. works part-time for a private company, Genomics plc.
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Gaffney, D.J. Mapping and predicting gene–enhancer interactions. Nat Genet 51, 1662–1663 (2019). https://doi.org/10.1038/s41588-019-0540-6
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DOI: https://doi.org/10.1038/s41588-019-0540-6
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