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Modeling the cooperativity of schizophrenia risk genes

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Common genetic variants increase the risk of schizophrenia, but the downstream biological mechanisms are largely unknown. A new study demonstrates that schizophrenia risk genes cause neuronal dysfunction and have synergistic effects on gene expression.

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Fig. 1: A genetics-anchored multifaceted approach to study the biological etiopathogenesis of schizophrenia.

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Authors and Affiliations

  1. The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Center for Genomics and Personalized Medicine, Center for Integrative Sequencing, iSEQ and Department of Biomedicine, Aarhus University, Aarhus, Denmark

    Jane H. Christensen & Anders D. Børglum

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  1. Jane H. Christensen
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  2. Anders D. Børglum
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Corresponding authors

Correspondence to Jane H. Christensen or Anders D. Børglum.

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The authors declare no competing interests.

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Christensen, J.H., Børglum, A.D. Modeling the cooperativity of schizophrenia risk genes. Nat Genet 51, 1434–1436 (2019). https://doi.org/10.1038/s41588-019-0508-6

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