Far from being junk DNA, the pervasive retrotransposons that populate the genome have a powerful capacity to influence genes and chromatin. A new study demonstrates how the transcription of one such element, HERV-H, can modify the higher-order 3D structure of chromatin during early primate development.
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Robson, M.I., Mundlos, S. Jumping retroviruses nudge TADs apart. Nat Genet 51, 1304–1305 (2019). https://doi.org/10.1038/s41588-019-0491-y
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DOI: https://doi.org/10.1038/s41588-019-0491-y
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