Chromatin loops and domains are major organizational hallmarks of chromosomes. New work suggests, however, that these topological features of the genome are poor global predictors of gene activity, raising questions about their function.
References
Ghavi-Helm, Y. et al. Nat. Genet. https://doi.org/10.1038/s41588-019-0462-3 (2019).
Dekker, J. & Misteli, T. Cold Spring Harb. Perspect. Biol. 7, 019356 (2015).
Dixon, J. R., Gorkin, D. U. & Ren, B. Mol. Cell 62, 668–680 (2016).
Lupiáñez, D. G. et al. Cell 161, 1012–1025 (2015).
Nora, E. P. et al. Nature 485, 381–385 (2012).
Cattoni, D. I. et al. Nat. Commun. 8, 1753 (2017).
Bintu, B. et al. Science 362, eaau1783 (2018).
Finn, E. H. et al. Cell 176, 1502–1515.e10 (2019).
Symmons, O. & Raj, A. Mol. Cell 62, 788–802 (2016).
Halfton, M. S. Trends Genet. 35, 93–103 (2019).
Chen, H. et al. Nat. Genet. 50, 1296–1303 (2018).
Heinz, S. et al. Cell 174, 1522–1536.e22 (2018).
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Finn, E.H., Misteli, T. A genome disconnect. Nat Genet 51, 1205–1206 (2019). https://doi.org/10.1038/s41588-019-0476-x
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DOI: https://doi.org/10.1038/s41588-019-0476-x
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