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STRUCTURAL BIOLOGY

Mutagenesis-based protein structure determination

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Genetics has played a key role in understanding the relationship between the DNA sequence encoding a protein and the protein’s three-dimensional structure. Two new studies present similar analytical approaches to predict three-dimensional structure on the basis of genetic interaction data.

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Authors and Affiliations

  1. Department of Genome Sciences, University of Washington, Seattle, WA, USA

    Melissa Chiasson & Douglas M. Fowler

  2. Department of Bioengineering, University of Washington, Seattle, WA, USA

    Douglas M. Fowler

  3. Genetic Networks Program, CIFAR, Toronto, Ontario, Canada

    Douglas M. Fowler

Authors
  1. Melissa Chiasson
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  2. Douglas M. Fowler
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Correspondence to Douglas M. Fowler.

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The authors declare no competing interests.

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Chiasson, M., Fowler, D.M. Mutagenesis-based protein structure determination. Nat Genet 51, 1072–1073 (2019). https://doi.org/10.1038/s41588-019-0461-4

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  • DOI: https://doi.org/10.1038/s41588-019-0461-4

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