Skip to main content
SpringerLink
Log in

Reply to ‘Selective effects of heterozygous protein-truncating variants’

  • Correspondence
  • Published:

From Nature Genetics

View current issue Submit your manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Data availability

The data supporting the findings of this study will be made available, and can be requested from the authors prior to their publication.

References

  1. Charlesworth, B. & Hill, W. G. Nat. Genet. https://doi.org/10.1038/s41588-018-0291-9 (2018).

  2. Cassa, C. A. et al. Nat. Genet. 49, 806–810 (2017).

    Article  CAS  Google Scholar 

  3. Weghorn, D. et al. Preprint at https://www.biorxiv.org/content/early/2018/10/03/433961 (2018).

  4. Nei, M. Proc. Natl Acad. Sci. USA 60, 517–524 (1968).

    Article  CAS  Google Scholar 

  5. Keinan, A. & Clark, A. G. Science 336, 740–743 (2012).

    Article  CAS  Google Scholar 

  6. Lek, M. et al. Nature 536, 285–291 (2016).

    Article  CAS  Google Scholar 

  7. Tennessen, J. A. et al. Science 337, 64–69 (2012).

    Article  CAS  Google Scholar 

  8. Harpak, A., Bhaskar, A. & Pritchard, J. K. PLoS Genet. 12, e1006489 (2016).

    Article  Google Scholar 

Download references

Acknowledgements

We would like to thank J. Berg, G. Sella, M. Przeworski and A. Kondrashov for their helpful suggestions and feedback.

Author information

Author notes

  1. Donate Weghorn

    Present address: Centre for Genomic Regulation, Barcelona, Spain

  2. These authors contributed equally: Christopher A. Cassa, Donate Weghorn, Daniel J. Balick, Daniel M. Jordan.

Authors and Affiliations

  1. Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

    Christopher A. Cassa, Donate Weghorn, Daniel J. Balick, David Nusinow & Shamil R. Sunyaev

  2. Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA

    Christopher A. Cassa, Donate Weghorn, Daniel J. Balick & Shamil R. Sunyaev

  3. Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA

    Christopher A. Cassa, Daniel G. MacArthur, Mark J. Daly & Shamil R. Sunyaev

  4. Department of Genetic and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA

    Daniel M. Jordan

  5. Analytic and Translational Genetics Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

    Kaitlin E. Samocha, Anne O’Donnell-Luria, Daniel G. MacArthur & Mark J. Daly

  6. Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA, USA

    Kaitlin E. Samocha

  7. Division of Genetics and Genomics, Boston Children’s Hospital, Boston, MA, USA

    Anne O’Donnell-Luria

  8. Center for Developmental Biology and Regenerative Medicine, Seattle Children’s Research Institute, Seattle, WA, USA

    David R. Beier

  9. Department of Pediatrics, University of Washington School of Medicine, Seattle, WA, USA

    David R. Beier

Authors
  1. Christopher A. Cassa
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Donate Weghorn
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Daniel J. Balick
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Daniel M. Jordan
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. David Nusinow
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Kaitlin E. Samocha
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Anne O’Donnell-Luria
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Daniel G. MacArthur
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Mark J. Daly
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. David R. Beier
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Shamil R. Sunyaev
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to David R. Beier or Shamil R. Sunyaev.

Ethics declarations

Competing interests

The authors declare no competing interests.

Supplementary information

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Cassa, C.A., Weghorn, D., Balick, D.J. et al. Reply to ‘Selective effects of heterozygous protein-truncating variants’. Nat Genet 51, 3–4 (2019). https://doi.org/10.1038/s41588-018-0301-y

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41588-018-0301-y

  • Springer Nature America, Inc.

Search

Navigation