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Pioneering the chromatin landscape

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New genomic analyses indicate that pioneer transcription factors can sample a diverse repertoire of common binding sites among different cell types and become enriched where they cooperate with other factors specific to each cell. Pioneer-factor binding is mechanistically separate from, and is necessary for, subsequent phenomena of chromatin opening and epigenetic memory in vivo.

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Fig. 1: Dynamics of pioneer-factor activity.

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Authors and Affiliations

  1. Institute for Regenerative Medicine, Epigenetics Program, Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania Smilow Center for Translational Research, Philadelphia, PA, USA

    Kenneth S. Zaret

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  1. Kenneth S. Zaret
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Correspondence to Kenneth S. Zaret.

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The author declares no competing financial interests.

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Zaret, K.S. Pioneering the chromatin landscape. Nat Genet 50, 167–169 (2018). https://doi.org/10.1038/s41588-017-0038-z

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