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ENHANCER EPIGENETICS

Is H3K4me1 at enhancers correlative or causative?

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H3K4me1 is enriched at active and primed enhancers. However, whether H3K4me1 controls or simply correlates with enhancer activity and function has remained unclear. Several recent reports, including two in Nature Genetics, provide major mechanistic and functional insights into the role of H3K4me1 at enhancers.

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Fig. 1: H3K4me1 at enhancers: a chicken or the egg problem?

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Authors and Affiliations

  1. Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany

    Alvaro Rada-Iglesias

  2. Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases, Cologne, Germany

    Alvaro Rada-Iglesias

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  1. Alvaro Rada-Iglesias
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Correspondence to Alvaro Rada-Iglesias.

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The author declares no competing financial interests.

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Rada-Iglesias, A. Is H3K4me1 at enhancers correlative or causative?. Nat Genet 50, 4–5 (2018). https://doi.org/10.1038/s41588-017-0018-3

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