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A conditional, zinc-finger-dependent recombinase system for DNA editing

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By applying the logic of conditional enzymes, we have developed a zinc-finger-dependent recombinase system, the editing activity of which is induced by zinc finger DNA binding. The system combines the precision of recombinases with the DNA target site programmability of zinc finger domains.

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Fig. 1: The zinc-finger-dependent recombinase system.

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This is a summary of: Mukhametzyanova, L. et al. Activation of recombinases at specific DNA loci by zinc-finger domain insertions. Nat. Biotechnol. https://doi.org/10.1038/s41587-023-02121-y (2024).

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A conditional, zinc-finger-dependent recombinase system for DNA editing. Nat Biotechnol (2024). https://doi.org/10.1038/s41587-023-02122-x

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  • DOI: https://doi.org/10.1038/s41587-023-02122-x

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