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Gene editing

An optimized toolkit for prime editing

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Prime editing in vivo is systematically improved with an eye to clinical translation.

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Fig. 1: Co-delivery of dual v3em PE-AAV.

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Authors and Affiliations

  1. Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada

    Ryan M. Marks, Evgueni A. Ivakine & Ronald D. Cohn

  2. Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada

    Ryan M. Marks, Evgueni A. Ivakine & Ronald D. Cohn

  3. Division of Clinical Immunology & Allergy, Department of Pediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada

    Ori Scott

  4. Department of Physiology, University of Toronto, Toronto, Canada

    Evgueni A. Ivakine

  5. Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada

    Ronald D. Cohn

Authors
  1. Ryan M. Marks
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  2. Ori Scott
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  3. Evgueni A. Ivakine
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  4. Ronald D. Cohn
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Corresponding author

Correspondence to Ronald D. Cohn.

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The authors declare no competing interests.

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Marks, R.M., Scott, O., Ivakine, E.A. et al. An optimized toolkit for prime editing. Nat Biotechnol 42, 187–189 (2024). https://doi.org/10.1038/s41587-023-02091-1

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