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Gene editing

Cancer variant modeling in vivo

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Prime- and base-editor mouse models enable finely tuned, efficient functional studies of cancer-associated genetic changes.

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Fig. 1: Modeling the diverse mutational landscape of cancer using base- and prime-editing approaches.

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Authors and Affiliations

  1. Personalised Cancer Therapeutics Laboratory, Garvan Institute of Medical Research, Sydney, New South Wales, Australia

    Aji Istadi, Sean Porazinski & Marina Pajic

  2. St Vincent’s Clinical School, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia

    Sean Porazinski & Marina Pajic

Authors
  1. Aji Istadi
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  2. Sean Porazinski
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  3. Marina Pajic
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Corresponding author

Correspondence to Marina Pajic.

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The authors declare no competing interests.

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Istadi, A., Porazinski, S. & Pajic, M. Cancer variant modeling in vivo. Nat Biotechnol 42, 383–385 (2024). https://doi.org/10.1038/s41587-023-02080-4

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