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Metabolically enhanced CAR T cells efficiently clear solid tumors in mice

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Chimeric antigen receptor (CAR) T cells in the solid tumor microenvironment enter a partially dysfunctional state called T cell exhaustion. Interleukin (IL)-10-producing CAR T cells retain their metabolic fitness, resist T cell exhaustion and display unprecedented antitumor activity indicated by high cure rates and durable responses in mice. Clinical studies of IL-10-producing CAR T cells are underway.

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Fig. 1: IL-10-producing CAR T cells retain mitochondrial fitness and clear solid tumors.

References

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This is a summary of: Zhao, Y. et al. IL-10-expressing CAR T cells resist dysfunction and mediate durable clearance of solid tumors and metastases. Nat. Biotechnol. https://doi.org/10.1038/s41587-023-02060-8 (2024).

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Metabolically enhanced CAR T cells efficiently clear solid tumors in mice. Nat Biotechnol (2024). https://doi.org/10.1038/s41587-023-02061-7

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  • DOI: https://doi.org/10.1038/s41587-023-02061-7

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