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DNA nanodevices map intracellular ions

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Two DNA nanodevices, RatiNa and pHlicker, provide precise mapping of sodium levels in acidic organelles and potassium activity at a single-organelle resolution.

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Fig. 1: DNA-based nanodevices for imaging organellar Na+ and K+.

References

  1. Anees, P. Nat. Biotechnol. https://doi.org/10.1038/s41587-023-01928-z (2023).

    Article  PubMed  Google Scholar 

  2. Zhou, J. Nat. Biotechnol. https://doi.org/10.1038/s41587-023-01950-1 (2023).

    Article  PubMed  Google Scholar 

  3. Xu, H. & Ren, D. Annu. Rev. Physiol. 77, 57–80 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Morth, J. P. et al. Nat. Rev. Mol. Cell Biol. 12, 60–70 (2011).

    Article  CAS  PubMed  Google Scholar 

  5. Li, P., Gu, M. & Xu, H. Trends Biochem. Sci. 44, 110–124 (2019).

    Article  PubMed  Google Scholar 

  6. Saminathan, A. et al. Nat. Nanotechnol. 16, 96–103 (2021).

    Article  CAS  PubMed  Google Scholar 

  7. Wang, X. et al. Cell 151, 372–383 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Hu, M., Zhou, N., Cai, W. & Xu, H. J. Cell Biol. 221, e202109133 (2022).

    Article  CAS  Google Scholar 

  9. Chen, Y. J., Groves, B., Muscat, R. A. & Seelig, G. Nat. Nanotechnol. 10, 748–760 (2015).

    Article  CAS  PubMed  Google Scholar 

  10. Du, Y. et al. Nat. Nanotechnol. 18, 818–827 (2023).

    Article  CAS  PubMed  Google Scholar 

  11. Narayanaswamy, N. et al. Nat. Methods 16, 95–102 (2019).

    Article  CAS  PubMed  Google Scholar 

  12. Xu, H., Martinoia, E. & Szabo, I. Cell Calcium 58, 1–10 (2015).

    Article  PubMed  PubMed Central  Google Scholar 

  13. Steinberg, B. E. et al. J. Cell Biol. 189, 1171–1186 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

I thank Yutong Zhang for helpful discussions and artwork.

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Authors and Affiliations

  1. Department of Neurology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China

    Haoxing Xu

  2. Liangzhu Laboratory & School of Basic Medical Sciences, Zhejiang University, Hangzhou, China

    Haoxing Xu

  3. Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI, USA

    Haoxing Xu

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  1. Haoxing Xu
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Correspondence to Haoxing Xu.

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Competing interests

H.X. is the scientific co-founder and a partial owner of Lysoway Therapeutics Inc (Boston, MA).

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Xu, H. DNA nanodevices map intracellular ions. Nat Biotechnol (2023). https://doi.org/10.1038/s41587-023-02054-6

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