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Genetic engineering

Novel recombinases for large DNA insertions

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Bioinformatic mining and engineering of serine recombinases yields improved genome editing tools.

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Fig. 1: Improved tools for large-scale DNA insertions using large serine recombinases (LSRs).

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Authors and Affiliations

  1. Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA

    George D. Lampe & Samuel H. Sternberg

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  1. George D. Lampe
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  2. Samuel H. Sternberg
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Correspondence to Samuel H. Sternberg.

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Competing interests

S.H.S. is a co-founder and scientific advisor to Dahlia Biosciences, a scientific advisor to Prime Medicine and CrisprBits, and an equity holder in Dahlia Biosciences and CrisprBits.

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Lampe, G.D., Sternberg, S.H. Novel recombinases for large DNA insertions. Nat Biotechnol 41, 471–472 (2023). https://doi.org/10.1038/s41587-022-01600-y

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