Skip to main content
SpringerLink
Log in

Lactate measurements in an integrated perfusion machine for human livers

  • Matters Arising
  • Published:

From Nature Biotechnology

View current issue Submit your manuscript

Matters Arising to this article was published on 26 October 2020

The Original Article was published on 13 January 2020

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Data availability

The data that support the findings in this paper are available from the corresponding author on request.

References

  1. Eshmuminov, D. et al. An integrated perfusion machine preserves injured human livers for 1 week. Nat Biotechnol. 38, 189–198 (2020).

  2. Mergental, H. et al. Development of clinical criteria for functional assessment to predict primary nonfunction of high-risk livers using normothermic machine perfusion. Liver Transpl. 24, 1453–1469 (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  3. Mergental, H. et al. Transplantation of declined liver allografts following normothermic ex-situ evaluation. Am. J. Transpl. 16, 3235–3245 (2016).

    Article  CAS  Google Scholar 

  4. Watson, C. J. E. et al. Observations on the ex situ perfusion of livers for transplantation. Am. J. Transpl. 18, 2005–2020 (2018).

    Article  CAS  Google Scholar 

  5. Nasralla, D. et al. A randomized trial of normothermic preservation in liver transplantation. Nature 557, 50–56 (2018).

    Article  CAS  PubMed  Google Scholar 

  6. Bral, M. et al. A back‐to‐base experience of human normothermic ex situ liver perfusion: does the chill kill? Liver Transpl. 25, 848–858 (2019).

    Article  PubMed  Google Scholar 

  7. Matton, A. P. M. et al. Biliary bicarbonate, pH, and glucose are suitable biomarkers of biliary viability during ex situ normothermic machine perfusion of human donor livers. Transplantation 103, 1405–1413 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Troyanov, S. et al. Solute clearances during continuous venovenous haemofiltration at various ultrafiltration flow rates using Multiflow-100 and HF1000 filters. Nephrol. Dialysis Transplant. 18, 961–966 (2003).

    Article  Google Scholar 

  9. Cerdá, J. et al. Critical care nephrology: management of acid–base disorders with CRRT. Kidney Int. 82, 9–18 (2012).

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. The Liver Unit, Queen Elizabeth Hospital Birmingham, Edgbaston, Birmingham, UK

    Barney T. F. Stephenson, Simon C. Afford, Hynek Mergental & Darius F. Mirza

  2. NIHR Biomedical Research Centre and Centre for Liver Research, The Institute for Immunology and Immunotherapy, University of Birmingham, Edgbaston, Birmingham, UK

    Barney T. F. Stephenson, Simon C. Afford, Hynek Mergental & Darius F. Mirza

Authors
  1. Barney T. F. Stephenson
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Simon C. Afford
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Hynek Mergental
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Darius F. Mirza
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

B.T.F.S. contributed the original idea, draft and further editing. S.C.A. contributed scientific advice and editing. H.M. contributed editing. D.F.M. contributed clinical advice and final proof editing.

Corresponding author

Correspondence to Darius F. Mirza.

Ethics declarations

Competing interests

The authors declare no competing interests.

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Stephenson, B.T.F., Afford, S.C., Mergental, H. et al. Lactate measurements in an integrated perfusion machine for human livers. Nat Biotechnol 38, 1259 (2020). https://doi.org/10.1038/s41587-020-0626-9

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41587-020-0626-9

  • Springer Nature America, Inc.

This article is cited by

Search

Navigation