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GENE EDITING

To BE or not to BE, that is the question

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In vivo studies indicate that cytosine but not adenine base editors induce elevated levels of genome-wide off-target substitutions.

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Fig. 1: Cas9- and BE-mediated editing.

References

  1. Rees, H. A. & Liu, D. R. Nat. Rev. Genet. 19, 770–788 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Zuo, E. et al. Science https://doi.org/10.1126/science.aav9973 (2019).

  3. Jin, S. et al. Science https://doi.org/10.1126/science.aaw7166 (2019).

  4. Kim, D., Kim, D. E., Lee, G., Cho, S. I. & Kim, J. S. Nat. Biotechnol. https://doi.org/10.1038/s41587-019-0050-1 (2019).

    Article  PubMed  PubMed Central  Google Scholar 

  5. Haapaniemi, E., Botla, S., Persson, J., Schmierer, B. & Taipale, J. Nat. Med. 24, 927–930 (2018).

    Article  CAS  PubMed  Google Scholar 

  6. Kosicki, M., Tomberg, K. & Bradley, A. Nat. Biotechnol. 36, 765–771 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Kim, D. et al. Nat. Biotechnol. 35, 475–480 (2017).

    Article  CAS  PubMed  Google Scholar 

  8. Yang, B., Li, X., Lei, L. & Chen, J. J. Genet. Genomics 44, 423–437 (2017).

    Article  PubMed  Google Scholar 

  9. Kim, Y. B. et al. Nat. Biotechnol. 35, 371–376 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Wang, X. et al. Nat. Biotechnol. 36, 946–949 (2018).

    CAS  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. School of Life Science and Technology, ShanghaiTech University, Shanghai, China

    Jia Chen

  2. Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, China

    Bei Yang

  3. CAS Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China

    Li Yang

Authors
  1. Jia Chen
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  2. Bei Yang
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  3. Li Yang
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Correspondence to Jia Chen, Bei Yang or Li Yang.

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The authors declare no competing financial interests.

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Chen, J., Yang, B. & Yang, L. To BE or not to BE, that is the question. Nat Biotechnol 37, 520–522 (2019). https://doi.org/10.1038/s41587-019-0119-x

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