Human brain organoids are endowed with regional topography using engineered signaling centers.
References
Pașca, S. P. Nature 553, 437–445 (2018).
Cederquist, G. Y. et al. Nat. Biotechnol.. https://doi.org/10.1038/s41587-019-0085-3 (2019).
Silbereis, J. C., Pochareddy, S., Zhu, Y., Li, M. & Sestan, N. Neuron 89, 248–268 (2016).
Kiecker, C. & Lumsden, A. Annu. Rev. Neurosci. 35, 347–367 (2012).
Ericson, J. et al. Cell 81, 747–756 (1995).
Lupo, G., Harris, W. A. & Lewis, K. E. Nat. Rev. Neurosci. 7, 103–114 (2006).
Birey, F. et al. Nature 545, 54–59 (2017).
Blassberg, R., Macrae, J. I., Briscoe, J. & Jacob, J. Hum. Mol. Genet. 25, 693–705 (2016).
Sakaguchi, H. et al. Nat. Commun. 6, 8896 (2015).
Jo, J. et al. Cell Stem Cell 19, 248–257 (2016).
Martyn, I., Kanno, T. Y., Ruzo, A., Siggia, E. D. & Brivanlou, A. H. Nature 558, 132–135 (2018).
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Miura, Y., Pașca, S.P. Polarizing brain organoids. Nat Biotechnol 37, 377–378 (2019). https://doi.org/10.1038/s41587-019-0084-4
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DOI: https://doi.org/10.1038/s41587-019-0084-4
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