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The new liver epidemic

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NASH has replaced hepatitis C as the most important nonalcoholic liver disease. Biotech and pharma are racing to tap into this enormous market.

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References

  1. Perry, R. J., Samuel, V. T., Petersen, K. F. & Shulman, G. I. Nature 510, 84–91 (2014).

    Article  CAS  Google Scholar 

  2. Sanyal, A. J. et al. N. Engl. J. Med. 362, 1675–1685 (2010).

    Article  CAS  Google Scholar 

  3. Huang, M. A. et al. Am. J. Gastroenterol. 100, 1072–1081 (2005).

    Article  Google Scholar 

  4. Promrat, K. et al. Hepatology 51, 121–129 (2010).

    Article  CAS  Google Scholar 

  5. Parks, D. J. et al. Science 284, 1365–1368 (1999).

    Article  CAS  Google Scholar 

  6. Holt, J. A. et al. Genes Dev. 17, 1581–1591 (2003).

    Article  CAS  Google Scholar 

  7. Neuschwander-Tetri, B. A. et al. Lancet 385, 956–965 (2015).

    Article  CAS  Google Scholar 

  8. Loomba, R. et al. Hepatology 67, 549–559 (2018).

    Article  CAS  Google Scholar 

  9. Pawlak, M. et al. Hepatology 60, 1593–1606 (2014).

    Article  CAS  Google Scholar 

  10. Ratziu, V. et al. Gastroenterology 150, 1147–1159 (2016).

    Article  CAS  Google Scholar 

  11. Friedman, S. L. et al. Hepatology 67, 1754–1767 (2018).

    Article  CAS  Google Scholar 

  12. Armstrong, M. J. et al. Lancet 387, 679–690 (2016).

    Article  CAS  Google Scholar 

  13. Patel, K. et al. Hepatology 68 (Suppl. 1), 438A, abstract 736 (2018).

  14. Luo, J. et al. Sci. Transl. Med. 6, 247ra100 (2014).

    Article  Google Scholar 

  15. Harrison, S. A. et al. Lancet 391, 1174–1185 (2018).

    Article  CAS  Google Scholar 

  16. Romeo, S. et al. Nat. Genet. 40, 1461–1465 (2008).

    Article  CAS  Google Scholar 

  17. Yuan, X. et al. Am. J. Hum. Genet. 83, 520–528 (2008).

    Article  CAS  Google Scholar 

  18. Linden D. et al. Hepatology 68 (Supp. 1), 440A, abstract 740 (2018).

  19. Kozlitina, J. et al. Nat. Genet. 46, 352–356 (2014).

    Article  CAS  Google Scholar 

  20. Abul-Husn, N. S. et al. N. Engl. J. Med. 378, 1096–1106 (2018).

    Article  CAS  Google Scholar 

  21. Ma, Y. et al. Hepatology https://doi.org/10.1002/hep.30350 (2018).

  22. About, F., Abel, L. & Cobat, A. N. Engl. J. Med. 379, 1875–1876 (2018).

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Garber, K. The new liver epidemic. Nat Biotechnol 37, 209–214 (2019). https://doi.org/10.1038/s41587-019-0047-9

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