Bladder cancer progression to microscopically distinct variants such as sarcomatoid, small cell, micropapillary and plasmacytoid is associated with more aggressive clinical behaviour than conventional carcinoma. Advances in molecular profiling led to the identification of molecular subtypes of bladder cancer and provided insights into disease progression to aggressive variants.
References
Robertson, A. G. et al. Comprehensive molecular characterization of muscle-invasive bladder cancer. Cell 171, 540–556.e25 (2017).
Guo, C. C. et al. Molecular profile of bladder cancer progression to clinically aggressive subtypes. Nat. Rev. Urol. https://doi.org/10.1038/s41585-023-00847-7 (2024).
Guo, C. C. et al. Gene expression profile of the clinically aggressive micropapillary variant of bladder cancer. Eur. Urol. 70, 611–620 (2016).
Al-Ahmadie, H. A. et al. Frequent somatic CDH1 loss-of-function mutations in plasmacytoid variant bladder cancer. Nat. Genet. 48, 356–358 (2016).
Guo, C. C. et al. Dysregulation of EMT drives the progression to clinically aggressive sarcomatoid bladder cancer. Cell Rep. 27, 1781–1793.e4 (2019).
Yang, G. et al. Urothelial-to-neural plasticity drives progression to small cell bladder cancer. iScience 23, 101201 (2020).
McFadden, J. et al. Impact of variant histology on upstaging and survival in patients with nonmuscle invasive bladder cancer undergoing radical cystectomy. Urol. Oncol. 42, 69.e11–69.e16 (2024).
Ramos, P. et al. Prognostic impact of variant histology in bladder cancer: would early and aggressive treatment shift the paradigm? Urol. Oncol. 42, 161.e1–161.e8 (2024).
Claps, F. et al. Prognostic impact of variant histologies in urothelial bladder cancer treated with radical cystectomy. BJU Int. 132, 170–180 (2023).
Ginsburg, K. B. et al. Oncologic outcomes of cT1 and cT2 micropapillary variant compared with cT1 and cT2 conventional urothelial carcinoma treated with radical cystectomy. Urol. Pract. 9, 396–404 (2022).
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Czerniak, B. Bladder cancer variants — one disease with many faces. Nat Rev Urol (2024). https://doi.org/10.1038/s41585-024-00886-8
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DOI: https://doi.org/10.1038/s41585-024-00886-8
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