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KIDNEY CANCER

Hypoxia-inducible factor 2 inhibitors show promise in advanced kidney cancer

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A new phase I clinical trial has demonstrated that belzutifan provides a route to sustained inhibition of hypoxia-inducible factor 2α in humans that is well tolerated and could be useful in the treatment of advanced clear cell kidney cancer.

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Acknowledgements

P.H.M. acknowledges the support of the Wellcome Trust (no. 19710), the NIHR Cambridge Biomedical Research Centre and the Rosetrees Trust (no. G102721).

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Authors and Affiliations

  1. Cambridge Institute for Medical Research, The Keith Peters Building, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK

    Natalie Burrows & Patrick H. Maxwell

  2. Department of Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK

    Natalie Burrows & Patrick H. Maxwell

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  1. Natalie Burrows
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  2. Patrick H. Maxwell
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Correspondence to Patrick H. Maxwell.

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Competing interests

P.H.M. is a scientific founder and equity holder of ReOx Ltd and has received speaker honoraria from Fibrogen and Astellas. He has also undertaken consultancy work for Mission Therapeutics. N.B. declares no competing interests.

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Burrows, N., Maxwell, P.H. Hypoxia-inducible factor 2 inhibitors show promise in advanced kidney cancer. Nat Rev Urol 18, 516–517 (2021). https://doi.org/10.1038/s41585-021-00487-9

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