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Building confidence in circulating tumour DNA assays for metastatic castration-resistant prostate cancer

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Genomic alterations in metastatic castration-resistant prostate cancer can be identified in plasma circulating tumour DNA. A large cohort analysis shows reliable detection of clinically relevant alterations through targeted cell-free DNA sequencing with a commercial platform, paving the way for liquid biopsy technology to be integrated into routine clinical practice.

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Fig. 1: Consistent detection of DNA damage repair defects in patient-matched liquid biopsy and tissue biopsy samples.

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Authors and Affiliations

  1. Vancouver Prostate Centre, Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada

    Sarah W. S. Ng & Alexander W. Wyatt

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  1. Sarah W. S. Ng
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  2. Alexander W. Wyatt
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Correspondence to Alexander W. Wyatt.

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Competing interests

A.W.W. reports receiving a commercial research grant from Janssen and honoraria from AstraZeneca, Astellas, Janssen and Merck. S.W.S.N. declares no competing interests.

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Ng, S.W.S., Wyatt, A.W. Building confidence in circulating tumour DNA assays for metastatic castration-resistant prostate cancer. Nat Rev Urol 18, 255–256 (2021). https://doi.org/10.1038/s41585-021-00455-3

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