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Combining options in metastatic prostate cancer

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Intensifying systemic therapy improves outcomes in metastatic prostate cancer. As apalutamide and enzalutamide join abiraterone and docetaxel as treatment options for patients, the choice of therapy for individual patients becomes more complex. We anticipate precision targeted and immune therapies will build on the advances of recently completed large-scale trials.

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Authors and Affiliations

  1. Department of Urology, Oregon Health & Science University, Portland, OR, USA

    Ryan P. Kopp

  2. Urology Section, Portland VA Medical Center, Portland, OR, USA

    Ryan P. Kopp

  3. Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA

    Ryan P. Kopp & Tomasz M. Beer

Authors
  1. Ryan P. Kopp
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  2. Tomasz M. Beer
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Corresponding author

Correspondence to Tomasz M. Beer.

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Competing interests

T.M.B. has received research funding from Alliance Foundation Trials, Boehringer Ingelheim, Corcept Therapeutics, Endocyte Inc., Janssen Research & Development, Medivation, Inc./Astellas, OncoGenex, Sotio and Theraclone Sciences/OncoResponse, consulting fees from AbbVie, Astellas Pharma, AstraZeneca, Bayer, Boehringer Ingelheim, Clovis Oncology, GlaxoSmithKline, Janssen Biotech, Janssen Japan, Merck and Pfizer and owns stock in Salarius Pharmaceuticals. R.P.K. has received research funding from Merck and Roche.

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Related links

NCT01957436: https://clinicaltrials.gov/ct2/show/NCT01957436

NCT02799602: https://clinicaltrials.gov/ct2/show/NCT02799602

NCT03678025: https://clinicaltrials.gov/ct2/show/NCT03678025

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Kopp, R.P., Beer, T.M. Combining options in metastatic prostate cancer. Nat Rev Urol 16, 569–570 (2019). https://doi.org/10.1038/s41585-019-0217-z

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